Mutagenic research colchicine human sperm

Five animals were treated per dose group and sperm aneuploidy was evaluated in 10 sperm per animal. Reprod Toxicol ; An investigation of the DNA-damaging ability of benzene and its metabolites in human lymphocytes, using the comet assay. Environ Health Perspect ; 1: The drug binds to microtubule-associated proteins, thereby affecting chromosome segregation in both mitosis and meiosis [Roobol et al. J Agric Food Chem.

National Center for Preclinical Reproductive and Genetic Toxicology, National Institute for Research in Reproductive Health, Indian Council of Medical Research ICMR , J. Open access Overview Open journals Open Select Cogent OA. Animals were examined throughout the experimental period for signs of gross toxicity. Plasma concentrations of chloral hydrate were dose dependent, but metabolic rates were unaffected by dose or sex. Please refer to this blog post for more information. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.

These types of chromosomes have the exceptional facility to merge with each other. Ravishankar , 3 and Varun B. An evaluation of the mouse sperm morphology test and other sperm tests in non-human mammals: DCA caused a significant change at 10 mM at 6 h; TCA, 1 mM at 1 h; CH and TCEth, 1 mM at 24 h; and PERC, 0. Commissioner of Social Security, 11th Cir.